20% Oxytetracycline Injection

Yellow to light brown yellow clear liquid.

Pharmacological Action
Pharmacodynamics Tetracyclines broad-spectrum antibiotics. Takes strong effect on staphylococcus, hemolytic streptococcus, anthrax, clostridium tetanus, clostridium and other gram-positive bacteria, but not strong as β-lactam. Sensitive to Escherichia coli, salmonella and pasteurella, brucella and other gram negative bacteria, but not as good as the aminoglycosides and amide alcohol antibiotics. The product is inhibited to rickettsia, chlamydia, mycoplasma, spirochetes, actinomycetes and some protozoa.
Pharmacokinetics The apparent volume of distribution of oxytetracycline in small animal is about 2.1L/kg, horse 1.4L/kg, cow 0.8L/kg. Oxytetracycline mainly excreted in prototype by the glomerular filtration. When there is renal dysfunction, excretion reduced and half-life extended. The half-life of oxytetracycline is 10.5 hours for horses, 4.3 to 9.7 hours for cattle, 6.7 hours for pigs, and 4 to 6 hours for dogs and cats.

Drug Interactions  
①Renal damage increased when administered together with strong diuretics such as furosemide. ②It is a rapid antibacterial agent, which can interfere with the bactericidal action of penicillin on the reproduction of bacteria, and should avoid administerring together with penicillin drugs. ③It can form insoluble complexes and reduce the absorption of drugs when administer with the calcium salt, iron salt, metal ion calcium, magnesium, aluminum, bismuth, iron and other drugs (including Chinese herbal medicine).

For the treatment of infections caused by gram positive bacteria, gram negative bacteria, rickettsiae, mycoplasma(such as pasteurellosis, brucellosis, anthrax,E. coli,Salmonella infections, acute respiratory infections, horse glanders, horse gland disease and mycoplasma pneumonia).
Usage and Dosage 
Intramuscular injection, for livestock 0.033~0.067ml/kg(contains Oxytetracycline l0~20mg)

Adverse Reactions
① There are local stimulation. Hydrochloric acid saline solution of this kind of drug has strong stimulation, when intramuscular injection it may cause pain, inflammation and necrosis.
② May cause intestinal flora disturbance. Tetracycline drugs have broad-spectrum inhibition on intestinal bacteria in horse, so resistant salmonella or unidentified pathogenic bacteria (including Clostridium, etc.)may cause secondary infection, leading to severe even fatal diarrhea. It often occurred after high-dose intravenous administration, but low-dose intramuscular injection may also occur.
③ Affecting tooth and bone growth. Tetracycline binds with calcium after into the body, and then deposition in the teeth and bones. This kind of drugs can through the placenta and into the milk easily, so pregnant, lactating animals and small animals disabled, during the treatment milk of lactating animals should ban on the market.
④ Damage to the liver and kidney. The product has toxic effect on liver and kidney cells. Tetracycline antibiotics can cause a variety of animal dose-dependent changes in renal function.
⑤ Anti-metabolic effects. Tetracycline drugs can cause nitrogenemia which can be exacerbated by steroids. The product can also cause metabolic acidosis and electrolyte imbalance.

(1) This product should be kept away from light and kept in a cool dry place. Avoid sunlight. Do not use metal containers.
(2) Sometimes horse may occur gastroenteritis after injection, should be used with caution.
(3) Livestock suffering from liver or kidney function severely damaged should avoid using.

Withdrawal Period
Cattle, sheep, pig, for 28 days; discard time, for 7 days.

Each  50ml contains Oxytetracycline 10g.

50ml per bottle

Shade, sealed, cool dark place to save.

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